胰岛素负荷对大鼠肥大细胞的影响。

F B Shapiro, B A Umarova
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引用次数: 0

摘要

经0.3 U/200 g胰岛素静脉注射30 min后,大鼠肾包膜肥大细胞和皮下脂肪分泌肝素增加(此时血糖浓度降低40%)。肝素处理后肥大细胞饱和指数分别下降2.3倍和1.9倍。初步给予硫酸鱼精蛋白(2mg / 200g),引起大鼠对胰岛素降糖作用的暂时抵抗状态,胰岛素对肥大细胞功能的刺激作用不会发生。
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[The effect of an insulin load on rat mast cells].

The increase of heparin secretion by mast cells of kidney capsule and subcutaneous fat has been noted in rats after 30 min intravenous insulin administration in a dose 0.3 U/200 g (by this time the blood sugar concentration lowers by 40%). The index of mast cells saturation with heparin drops by 2.3 and 1.9 times correspondingly. After preliminary administration of protamine sulphate (2 mg/200 g that provokes in rats the status of temporary resistance to the hypoglycemic action of insulin the stimulatory effect of insulin on the function of mast cells does not occur.

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