[精氨酸抗利尿激素和去甘氨酸-(8-精氨酸)抗利尿激素的条件反应消退的减缓]。

Farmakologiia i toksikologiia Pub Date : 1991-09-01
N I Dubrovina, O S Papsuevich, G I Chipens
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引用次数: 0

摘要

在小鼠实验中,分析了精氨酸-抗利尿激素(AVP)及其类似物去甘氨酸-精氨酸-抗利尿激素(DG-AVP)对皮肤电刺激后留置在单元危险区域致失忆症的被动回避条件反应消退和记忆痕迹再现的影响。在系统给药AVP和DG-AVP时,条件反应对急剧消失的抵抗力增加。
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[The slowing of the extinction of a conditioned reaction and the antiamnesic action of arginine vasopressin and des-glycine-(8-arginine) vasopressin].

In the experiments on mice there were analysed the effects of arginine-vasopressin (AVP) and its analogue des-glycine-arginine-vasopressin (DG-AVP) on the extinction of the conditioned reaction of passive avoidance and the reproduction of memory trace in amnesia caused by detaining the animal in the dangerous section of the unit after electrocutaneous stimulation. An increase of resistance of the conditioned reaction to a sharp extinction at systemic administration of AVP and DG-AVP was shown.

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