[肝素对扩散室骨髓单核细胞集落形成过程的影响]。

Farmakologiia i toksikologiia Pub Date : 1991-09-01
G K Popov, M S Bel'skiĭ, A G Pochinskiĭ
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引用次数: 0

摘要

在Wistar大鼠尾静脉注射肝素50、100、250 U的实验中,研究了给药后1、3、6、12、24小时肝素化动物的造血细胞、骨髓前体的集落形成能力和血浆的集落刺激活性。肝素被发现可以增加骨髓细胞的增殖活性-扩散微室(GM-CFUdc)的前体,刺激单核细胞,并提高实验动物血浆的集落刺激活性水平。
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[The effect of heparin on the process of colony formation from bone marrow mononuclears in a diffusion chamber].

In the experiments on Wistar rats to whom heparin was injected intravenously in the tail vein in doses of 50, 100 and 250 U, there were studied the colony-forming ability of the hemopoietic cells, the precursors of the bone marrow, and the colony-stimulating activity of the plasma of the heparinized animals 1, 3, 6, 12 and 24 hours after the drug administration. Heparin was found to increase the proliferative activity of the committed myelopoietic cells-precursors on a diffusion microchamber (GM-CFUdc) stimulating the mononuclears and elevating the level of the colony-stimulating activity of the plasma of the experimental animals.

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