[乙酰半胱氨酸对实验性肝毒性损伤中抗氧化系统的影响]。

Farmakologiia i toksikologiia Pub Date : 1991-09-01
Ia I Gonskiĭ, M M Korda, I N Klishch
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引用次数: 0

摘要

CCl4对白化病大鼠的肝损伤伴随着脂质过氧化过程的剧烈激活和抗氧化系统大部分成分的抑制。对患病动物给予乙酰半胱氨酸,其积极作用表现为血浆和肝脏中脂质过氧化产物含量的降低和抗氧化保护系统的部分正常化。
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[The effect of acetylcysteine on the antioxidant system in an experimental toxic lesion of the liver].

The liver damage by CCl4 in albino rats was followed by a drastic activation of lipid peroxidation processes and suppression of most components of the antioxidant system. The administration of acetylcysteine to the affected animals exerted the positive effect which manifested itself in a decrease of lipid peroxidation products content in the blood plasma and liver and in the partial normalization of the antioxidant protection system.

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