回顾性分析颅内脑膜瘤在三级卫生保健机构在中北部尼日利亚

P. Akpa, B. Kwaghe, E. Innocent, B. Otene, Dominic Akolo Azagaku, I. Okwudire-Ejeh
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前言/目的:关于尼日利亚和非洲其他地区脑膜瘤的详细出版文献很少。本研究旨在探讨我国三级医疗机构脑膜瘤的人口统计学、组织病理学和表现症状/体征,并将其与其他已发表的文献进行比较。方法:这是一项基于医院的回顾性研究,对尼日利亚中北部高原州乔斯大学教学医院组织病理学诊断的所有脑膜瘤病例进行研究。审查期为2012年1月1日至2020年12月31日。本研究使用的材料包括组织病理学玻片、石蜡组织块、电子手术病理结果数据库、电子癌症登记条目和患者病例档案的硬拷贝。记录所有病例的年龄、性别、颅内位置、组织形态学变异、分级和表现的症状/体征并进行分析。结果:9年来,87例原发性颅内肿瘤中34例经组织病理学诊断为脑膜瘤。雌性为优势,M:F为1:1.61。女性和男性的诊断高峰年龄分别出现在5岁和6岁。最常见的组织形态学变异是脑膜上皮型,最常见的颅内诊断部位是凸起。最常见的症状/体征是头痛、癫痫发作和视力障碍。结论:脑膜瘤是尼日利亚中北部乔斯大学教学医院最常见的颅内肿瘤。在我们的环境中,这种肿瘤发生在相对年轻的年龄。在我们的研究中,这种肿瘤的性别分布、变异、等级和症状/体征与世界其他地区的研究结果一致。
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A Retrospective Analysis of Intracranial Meningiomas in a Tertiary Health Care Facility in North Central Nigeria
Introduction/Aim: There is scanty detailed published literature on meningiomas in Nigeria and other parts of Africa. This study is aimed at exploring the demographics, histopathology and presenting symptoms/signs of meningioma in our tertiary health facility and comparing it with other published literature. Methodology: This is a hospital based retrospective study of all histopathologically diagnosed meningioma cases at the department of histopathology of the Jos University Teaching Hospital in plateau state North-Central Nigeria. The period of review is between the 1st of January 2012 to the 31st of December 2020. Materials utilized for this research consisted of Archival histopathology glass slides, paraffin wax tissue blocks, electronic surgical pathology result data base, electronic cancer registry entries and hard copies of patient case files. The age, sex, intracranial location, histomorphological variant, grade and presenting symptom/sign was documented for all cases and analyzed. Results: Thirty-four (34) cases of meningioma out of 87 primary intracranial neoplasms were histopathologically diagnosed over the 9 years of review. There was a female predominance, with a M:F of 1:1.61. The peak age of diagnoses occurred in the 5th and 6th decades for females and males respectively. The commonest histomorphological variant was the Meningothelial type with the commonest intracranial site of diagnosis being the convexities. The most frequently occurring presenting symptom/sign were headache, seizures and visual impairment. Conclusion: Meningioma is the commonest intracranial tumour diagnosed at the Jos University teaching Hospital, In North central Nigeria. This tumour occurs at a relatively younger age in our environment. The sex distribution, variants, grades and symptoms/signs of this tumour in our study conforms to what is obtainable in other parts of the world.
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