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引用次数: 1

摘要

姜黄素是一种多酚天然产物,是传统药物姜黄的一种成分。近50年来的广泛研究表明,这种多酚通过多种作用机制靶向许多关键细胞因子,显示出强大的药理作用。然而,有一些障碍阻止这种神奇的分子在临床环境中有效,并限制其仅用于局部应用。姜黄素最近被归类为panassay interference compounds (PAINS)和IMPS (invalid metabolic panacea)候选者。由于姜黄素在体外和体内可能存在假活性,导致姜黄素治疗多种疾病的临床试验不成功。本章将回顾姜黄素的基本药物化学,并设想姜黄素生物利用度差的汇编和讨论。
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Pharmacological Properties of Curcumin
Curcumin, the polyphenol natural product, is a constituent of the traditional medicine known as turmeric. Extensive research over the last 50 years has indicated that this polyphenol displays potent pharmacological effects by targeting many critical cellular factors through a diverse array of mechanisms of action. However, there are some obstacles that prevent this wonder molecule to be effective in clinical settings and limit its use to topical applications only. Curcumin has recently been classified as both PAINS (panassay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. Due to likely false activity of curcumin in vitro and in vivo has resulted unsuccessful clinical trial of curcumin against several disease. The chapter will review the essential medicinal chemistry of curcumin as well as envisage a compilation and discussion on the poor bioavailability of curcumin.
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