Neurogenically Originated Inflammatory Response Syndrome: Role in the Neurocritical Patient

The systemic inflammatory response syndrome (SIRS) consists of an inflammatory phenomenon as a response of the immune system against infections, as well as non-infectious injuries, which includes manifestations that affect multiple organs, among which hyperthermia or hypothermia, leukopenia or leukocytosis, tachycardia, and tachypnea. SIRS accompanies different acute brain and spinal cord injuries, including subarachnoid hemorrhage, intracerebral hemorrhage, spinal cord trauma, traumatic brain injury, and status epilepticus. We suggest a new term for this condition neurogenically originated systemic inflammatory response syndrome (NoSIRS). NIRS can be considered a new syndrome associated with pathological neurological conditions. However, more research is needed to figure out the true severity of this clinical picture and also figure out the best way to treat this condition.