卡氏肺囊虫在SCID小鼠群体中的引入。

The Journal of protozoology Pub Date : 1991-11-01

B Soulez, F Palluault, J Y Cesbron, E Dei-Cas, A Capron, D Camus

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引用次数: 0

摘要

无卡氏肺囊虫的SCID小鼠被安置在我们实验室动物设施的常规区域，与皮质类固醇治疗的非SCID小鼠密切接触。一天的接触就足以传播卡氏疟原虫。此后肺部感染增加。在暴露开始时对SCID小鼠进行照射或脾切除可导致寄生虫增殖显著增加。经空气传播感染卡氏假单胞菌的SCID小鼠的心脏和脾脏均可见肺囊虫病肺外灶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Introduction of Pneumocystis carinii in a colony of SCID mice.

Pneumocystis carinii-free SCID mice were housed closely exposed to corticosteroid-treated non-SCID mice in a conventional area of our laboratory animal facilities. A one-day exposure was sufficient for P. carinii transmission. The lung infection increased thereafter. Irradiation or splenectomy of SCID mice at the beginning of the exposure resulted in a marked increase of parasite multiplication. Extrapulmonary foci of pneumocystosis were detected in heart and spleen of SCID mice infected by P. carinii via air transmission.

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The Journal of protozoology

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