Comparison between PRP vs iPRF as an adjunct therapy in Infra-bony Pocket treatment

Objective: The aim of the present study was to adjunct the healing of intra bony periodontal deep pockets using minimal invasive technique and materials (injectable platelet rich fibrin-I PRF-). Subjects & Method: A total of 70 medically healthy adult subjects with chronic periodontitis in a randomized controlled clinical trial were divided into 3 groups; PRP group, iPRF group & control group. PRP preparation: Two Acid citric dextrose (ACD) 8.5 ml tubes of whole blood were centrifuged at 2000 rpm for 7 min at room temperature using Heraeus Megafuge 16R centrifuge. IPRF preparation: Two tubes (without anticoagulant) of 10 ml of whole blood were centrifuged at 700 rpm for 3 min at room temperature using Heraeus Megafuge 16R centrifuge. Results: Postoperative evaluation: I-PRF group showed the highest reduction of probing depth from baseline, while PRP group came second followed by the control group which had the lowest reduction in probing depth. Conclusion: the repeated injection of i- PRF showing a stronger and more durable effect, since it has number of growth factors which are responsible for tissue regeneration capable of inducing fibroblast behavior.