蛇毒作为一种有前途的药物发现工具的评估[专注于神经系统疾病]

Soodeh Omidi, M. Mehrpouya, M. Oladnabi, A. Azadmehr, F. Kazemi-Lomedasht, N. Yardehnavi
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引用次数: 1

摘要

毒液毒素具有特定的分子靶点,可导致毒性并发症,如神经毒性。在进化过程中,毒液的成分与分子靶点的进化是同步的。从两个不同的角度来看,毒液是人类的重要工具;毒液的优缺点。同时,由于毒液对生理因素或靶点的特异性靶向和调节,其临床和药理应用在各种疾病中都是值得注意的。对毒液及其组成的进一步了解,将有助于今后一些毒素类药物在药物储存中的实际应用。
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Evaluation of venom as a promising tool for drug discovery [focusing on Neurological disorders]
Venom toxins have specific molecular targets that result in envenomated complications such as neurotoxicity. During evolution, the composition of the venom has been evolved synchronously with the evolution of molecular targets. Venom is an important tool for humans from two different perspectives; venom advantages and disadvantages. Meanwhile, clinical and pharmacological applications of venoms due to their specific targeting and modulation of physiological elements or targets are notable in various disorders. The better understanding of venoms and their composition will improve the practical applications of some toxin-based drugs in drugstoresin the future.
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