The Effect of Pare (Momordica Charantia L.) Fruit Extract Fraction on Reducing Blood Sugar, Insulin Resistance and Phosphatidyl Inositol 3 Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-induced Hyperglycemia

Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is a metabolic disorder characterized by insulin receptor resistance, reduced ability of pancreatic -cells to secrete insulin, and abnormal insulin secretion from cells of the pancreatic islets of Langerhans. In insulin resistance, the signaling defect in Phosphatidylinositol 3-kinase (PI3K) causes impaired glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on lowering blood sugar, insulin resistance, and phosphatidylinositol 3kinase (PI3K) signaling. Method: Literature review studies from related journals. Results: Based on research conducted, it is known that bitter melon extract has an effect on blood sugar, insulin resistance, and PI3K signaling. Conclusion: Bitter gourd extract has potential as an herbal antidiuretic drug.