用于牙周治疗的可降解缓释装置的结构和微生物学评价。

Drug design and delivery Pub Date : 1991-01-01
M Friedman, D Steinberg, M N Sela, A Soskolne
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引用次数: 0

摘要

研究了含氯己定的可降解蛋白基质作为治疗牙周病的口袋内给药系统。该装置的性能主要取决于基质中的交联程度,而交联程度可以根据制备条件的不同而变化。根据蛋白质中游离赖氨酸的数量,通过氨基酸分析来确定交联程度。测定了氯己定的释放度和制备基质所用增塑剂的释放度。氯己定从基质中释放延长300小时,增塑剂在4小时后停止释放。有限的临床试验表明,其中一种可降解装置——含有最多的交联——在将其插入牙周病患者的牙周袋后,可显著减少牙周致病菌的数量。
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Structural and microbiological evaluation of a degradable sustained-release device for use in periodontal therapy.

Degradable protein matrices containing chlorhexidine were tested as intra-pocket drug delivery systems in the treatment of periodontal diseases. The properties of the device were mainly dependent upon the degree of cross linking in the matrix, which could be varied according to the preparative conditions. The degree of cross linking was determined by amino acid analysis based on the amount of free lysine in the protein. The release of chlorhexidine and of the plasticizer used in the preparation of the matrix were determined. The release of chlorhexidine from the matrix was prolonged for a period of 300 hours, and the release of plasticizer ceased after four hours. Limited clinical trials suggest that one of the degradable devices--that containing the highest amount of cross-linking--causes a significant reduction in the amount of perio-pathogenic bacteria following its insertion into the periodontal pockets of patients with periodontal disease.

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