[药物制剂的抗缺氧和抗缺血作用之间缺乏相似性]。

Farmakologiia i toksikologiia Pub Date : 1991-05-01
D M Lomtadze, I B Tsorin, E Iu Chirkova, G G Chichkanov
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引用次数: 0

摘要

在不同种类的动物(小鼠、猫)上的实验表明,药物的抗缺氧和抗缺血作用之间缺乏相似性。在四种被研究的抗缺氧药物(氧化丁酸锂、吡拉西坦、葡萄糖-6、嘧啶S-207的衍生物)中,只有GABA衍生物显示冠状动脉闭塞下静脉窦血液中乳酸/丙酮酸比值的增加,从而具有抗缺血特性。抗缺氧药对心肌作用的差异在一定程度上是由它们对冠状动脉侧枝血液循环的不同影响决定的。
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[The absence of a parallelism between the antihypoxic and anti-ischemic actions of pharmacological agents].

The experiments on different species of animals (mice, cats) showed the lack of parallelism between the antihypoxic and anti-ischemic effects of pharmacological agents. Of four studied antihypoxic agents (lithium oxybutyrate, piracetam, glyo-6, a derivative of pyrimidine S-207) only GABA derivatives showed an increase of the lactate/pyruvate ratio in the blood of the venous sinus under occlusion of the coronary artery and consequently possessed the anti-ischemic properties. Such difference in the effects of the antihypoxic agents on the myocardium was determined to a certain degree by their different influences on the collateral coronary blood circulation.

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