[抗抑郁药的镇痛活性及其对针灸镇痛效果的影响]。

Farmakologiia i toksikologiia Pub Date : 1991-05-01
Iu D Ignatov, Iu N Vasil'ev, V V Kolchin, A V Amelin, Kh Li Ch
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引用次数: 0

摘要

采用电刺激大鼠尾根,刺激强度递增的方法,研究了苏制新型抗抑郁药吡拉西多、印卡赞、丁替多与阿米替林的镇痛特性及其对针刺镇痛效果的影响。所有药物单次和亚慢性给药(6 d)均有镇痛作用。吡拉西多的效果最为显著。抗抑郁药增强了电针的镇痛效果,特别是在激活一般作用点时,这种效果在吡拉西醇治疗下表现得最大。
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[The analgetic activity of antidepressants and their influence on the pain-relieving effect of acupuncture].

The analgesic properties of new Soviet-made antidepressants pyrasidol, incazan, tetrindol as compared with amitriptyline and their influence on the analgesic effect of acupuncture were studied in experiments on rats by using the method of electrical stimulation of the tail root with stimuli of the increasing intensity. All the studied drugs at single and subchronic (6 days) administration possessed the analgesic actions. Pyrasidol exerted the most pronounced effect. The antidepressants enhanced the analgesic effect of electroacupuncture, in particular during activation of the points of general action and this effect showed up to the greatest degree under medication with pyrasidol.

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