系统性红斑狼疮(SLE)及类似疾病患者冻疮病史的评价

N Morioka, T Tsuchida, Y Ueda, Y Ishibashi
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摘要

我们对47例SLE及类似疾病患者进行了问卷调查,了解他们的冻疮病史。将这些患者的结果与141例对照组的结果进行比较。虽然经常出现冻疮的病例比例(40.0%)和冻疮发病年龄(平均:(10.8岁),与对照组(28.4%,12.4岁)差异无统计学意义,SLE患者发生冻疮的特点与对照组相比:(1)冻疮发作发生率高,(2)痊愈时间长,(3)冻疮导致糜烂或溃疡的可能性大,(4)冻疮多发于其他季节而非冬季。尤其是具有(4)特征的SLE患者雷诺现象、冻疮LE和livedo的相关率较高,提示外周循环紊乱。研究还显示,女性通常比男性更容易患冻疮(女性:40.0%,男性:13.1%)。这些结果提示冻疮与LE病变有一定的关系。推测具有上述特征的冻疮有可能转化为LE病变。
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[Evaluation of the past history of chilblain in cases of systemic lupus erythematosus (SLE) and its similar diseases].

We sent out a questionnaire to 47 patients of SLE and its similar diseases as to their past histories of chilblain. The results of the patients were compared to those of 141 cases of control. Although the percentage of cases who had revealed chilblain frequently (40.0%) and the age of chilblain onset (mean: 10.8 years old) in SLE group were not significantly different from those of control (28.4% and 12.4 years old, respectively), the chilblain which SLE patients developed had some characteristics compared to that of control, (1) higher incidence of chilblain episodes, (2) longer duration until cure, (3) more liability that chilblain leads to erosion or ulceration and (4) frequent occurrence of chilblain in the other seasons than winter. Especially SLE patients with the characteristic of (4) had higher association rates of Raynaud's phenomena, chilblain LE and livedo, suggesting disorder of peripheral circulation. It was also revealed that females are generally more liable to develop chilblain than males (females: 40.0%, males: 13.1%). Those results suggest some important relationship between chilblain and LE lesions. It is supposed that chilblain with the characteristics described above may possibly be transformed into LE lesions.

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[Bulla]. [Cell kinetic effects of crude coal tar application plus long wave ultraviolet radiation on normal and hyperproliferative epidermis of guinea pig skin]. [The partial characterization of neutrophils' and lymphocytes' chemotactic factors from murine anagenic hair bulb extract]. [Skin penetration of antimicrobial agents in rats]. [Urticarial erythema with neutrophilic infiltration--correlation of cutaneous vascular changes with clinical severity].
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