远端缺血及肾热性局部窒息药物预处理对内皮功能障碍的纠正

O. Bratchikov, M. Pokrovskiy, V. Elagin, D. A. Kostina
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引用次数: 1

摘要

本文包含了在模拟肾脏热性局部窒息过程中产生的内皮功能障碍的研究结果,以及通过远端缺血和药物预处理来纠正这些功能障碍的可能性。肾脏热性局部窒息模型的特点是微循环紊乱和肾组织中eNOS的表达。使用远端缺血预处理和磷酸二酯酶抑制剂5型西地那非和他他拉非可显著纠正微循环功能障碍和eNOS活性。在adma样L-NAME诱导的一氧化氮缺乏引起的肾热性局部窒息模型中,观察到更明显的微循环功能障碍和eNOS活性障碍。在5型磷酸二酯酶抑制剂的帮助下,在这种类型的病理中使用远端缺血和药理学预处理导致微循环功能障碍和eNOS活性的明显纠正。格列本脲受体阻滞剂在利用远端缺血和药理学预处理对肾热性局部窒息模型造成的干扰进行校正时,会导致其效率下降。披露:该研究没有赞助。作者已声明没有利益冲突。
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THE CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH THE HELP OF DISTANT ISCHEMIC AND PHARMACOLOGICAL PRECONDITIONING WITH THERMAL LOCAL ASPHYXIA OF KIDNEY
This article contains the results of research of the endothelial dysfunction arising during the modeling of thermal local asphyxia of kidney and possibilities of their correction by distant ischemic and pharmacological preconditioning. The modeling of thermal local asphyxia of kidney is characterized by the disturbance of microcirculation and expression of eNOS in the kidney tissue. The usage of distant ischemic preconditioning and phosphodiesterase inhibitors type 5 sildenafil and tadalafil leads to pronounced correction of microcirculation dysfunction and activity of eNOS. During the modeling of thermal local asphyxia of kidney against endothelium dysfunction caused by ADMA-like L-NAME induced deficiency of nitric oxide more pronounced dysfunction of microcirculation and activity of eNOS are observed. The usage of distant ischemic and pharmacological preconditioning with the help of phosphodiesterase inhibitors type 5 in this type of pathology led to pronounced correction of microcirculation dysfunction and activity of eNOS. The injection of glibenclamide blocker of ATP – dependent K+ channels during the correction of the disturbance caused by the modeling of thermal local asphyxia of kidney with the help of distant ischemic and pharmacological preconditioning leads to the decrease of its efficiency.Disclosure: The study did not have sponsorship. The authors have declared no conflicts of interest.
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