小鼠肝脏中胆红素和吗啡糖醛酸化不受环amp介导机制的抑制。

G Bánhegyi, T Garzó, G Mészáros, F Antoni, J Mandl
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引用次数: 0

摘要

据报道,生物转化的第一和第二阶段的一些反应是在负循环amp依赖的控制下进行的。分别在小鼠肝细胞和肝细胞微粒体中研究了胆红素的结合和吗啡的糖醛酸化。N6, o2 -二丁基环- amp在分离肝细胞中不抑制胆红素的结合。ATP和环amp依赖蛋白激酶的解离催化亚基不影响吗啡的葡萄糖醛酸化,而抑制小鼠肝细胞制备的微粒体中对硝基苯酚葡萄糖醛酸的形成。
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Bilirubin and morphine glucuronidation is not inhibited by a cyclic-AMP mediated mechanism in murine liver.

Several reactions of the Ist and IInd phase of biotransformation have been reported to be under a negative cyclic-AMP dependent control. Conjugation of bilirubin and glucuronidation of morphine were investigated in isolated mouse hepatocytes and in mouse hepatocyte microsomes, respectively. N6,O2-dibutyryl cyclic-AMP did not inhibit conjugation of bilirubin in isolated hepatocytes. ATP and the dissociated catalytic subunit of the cyclic-AMP dependent protein kinase did not influence the glucuronidation of morphine, while inhibited the formation of p-nitrophenol glucuronide in microsomes prepared from isolated mouse hepatocytes.

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