{"title":"甘露糖基化碳纳米管的设计、开发与表征","authors":"Sourabh Shukla","doi":"10.51129/ujpah-june2021-30-1(11)","DOIUrl":null,"url":null,"abstract":"Abstract - The proposed study was aimed at developing and exploring the efficiency of novel mannosylated MWCNTs. For selective drug delivery to alveolar macrophages, Paclitaxel was selected for incorporation into mannosylated MWCNTs based on its anticancer activity. Hopefully, this delivery system could be safely administered through i.v. route. We expect that this approach will improve management of drug therapy in cancer patients by delivering the drug at controlled rate for prolonged period of time at a desired site. The drug was found to be white to offwhite, crystalline powder that was similar in physical appearance as mentioned in I.P. 1996. Melting point of Paclitaxel was near to reported value. Solubility of the drug in different solvents at ambient temperature depicted its solubility in methanol, ethanol, acetone, dimethylsulphoxide and chloroform, while insoluble in distilled and PBS (pH 7.4). Drug entrapment efficiency of Paclitaxel loaded mannosylated MWCNTs was found to be increased. Keywords: Paclitaxel, Mannosylated MWCNTs, Anticancer, Solubility","PeriodicalId":432227,"journal":{"name":"Universities' Journal of Phytochemistry and Ayurvedic Heights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design Development and Characterization of Mannosylated Carbon Nanotubes\",\"authors\":\"Sourabh Shukla\",\"doi\":\"10.51129/ujpah-june2021-30-1(11)\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract - The proposed study was aimed at developing and exploring the efficiency of novel mannosylated MWCNTs. For selective drug delivery to alveolar macrophages, Paclitaxel was selected for incorporation into mannosylated MWCNTs based on its anticancer activity. Hopefully, this delivery system could be safely administered through i.v. route. We expect that this approach will improve management of drug therapy in cancer patients by delivering the drug at controlled rate for prolonged period of time at a desired site. The drug was found to be white to offwhite, crystalline powder that was similar in physical appearance as mentioned in I.P. 1996. Melting point of Paclitaxel was near to reported value. Solubility of the drug in different solvents at ambient temperature depicted its solubility in methanol, ethanol, acetone, dimethylsulphoxide and chloroform, while insoluble in distilled and PBS (pH 7.4). Drug entrapment efficiency of Paclitaxel loaded mannosylated MWCNTs was found to be increased. Keywords: Paclitaxel, Mannosylated MWCNTs, Anticancer, Solubility\",\"PeriodicalId\":432227,\"journal\":{\"name\":\"Universities' Journal of Phytochemistry and Ayurvedic Heights\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Universities' Journal of Phytochemistry and Ayurvedic Heights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51129/ujpah-june2021-30-1(11)\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Universities' Journal of Phytochemistry and Ayurvedic Heights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51129/ujpah-june2021-30-1(11)","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Design Development and Characterization of Mannosylated Carbon Nanotubes
Abstract - The proposed study was aimed at developing and exploring the efficiency of novel mannosylated MWCNTs. For selective drug delivery to alveolar macrophages, Paclitaxel was selected for incorporation into mannosylated MWCNTs based on its anticancer activity. Hopefully, this delivery system could be safely administered through i.v. route. We expect that this approach will improve management of drug therapy in cancer patients by delivering the drug at controlled rate for prolonged period of time at a desired site. The drug was found to be white to offwhite, crystalline powder that was similar in physical appearance as mentioned in I.P. 1996. Melting point of Paclitaxel was near to reported value. Solubility of the drug in different solvents at ambient temperature depicted its solubility in methanol, ethanol, acetone, dimethylsulphoxide and chloroform, while insoluble in distilled and PBS (pH 7.4). Drug entrapment efficiency of Paclitaxel loaded mannosylated MWCNTs was found to be increased. Keywords: Paclitaxel, Mannosylated MWCNTs, Anticancer, Solubility
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