血管肾素-血管紧张素系统在决定血管结构中是否有作用?

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158866
M J Mulvany
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引用次数: 5

摘要

本文综述了我的实验室在研究血管紧张素转换酶(ACE)抑制剂治疗对自发性高血压大鼠(SHRs)血压和小动脉结构的影响方面所做的工作。首先,数据证实,当停止治疗时,ACE抑制剂对SHRs患者的血压有持续的影响。ACE抑制剂的作用是剂量依赖性的,但持续作用不是剂量依赖性的。这表明,血管紧张素转换酶抑制剂对SHRs患者血压的持续影响不是通过血管结构介导的。其次,数据表明,尽管ACE抑制剂对血压和血管结构都具有剂量依赖性,但在使用不同药物的实验中,ACE抑制剂对血管结构的影响似乎主要通过其对血压的影响来解释,而不是任何特定的药物效应。
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Is there a role for the vascular renin-angiotensin system in the determination of vascular structure?

This paper reviews previous work done by my laboratory to investigate the effect of treatment with angiotensin-converting enzyme (ACE) inhibitors on blood pressure and small artery structure in spontaneously hypertensive rats (SHRs). First, the data confirm that ACE inhibitors have a persistent effect on blood pressure in SHRs when treatment is withdrawn. The effect of the ACE inhibitors was dose-dependent, but the persistent effect was not dose-dependent. This suggests that the persistent effect of ACE inhibitors on blood pressure in SHRs is not mediated through vascular structure. Secondly, the data demonstrate that, although ACE inhibitors have dose-dependent effects on both blood pressure and vascular structure, in experiments where different drugs were used, the effect of ACE inhibitors on vascular structure seems to be explained primarily through their effect on blood pressure, rather than any specific drugs effect.

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