Adaptive optical system for improved activation of PDT photosensitizers

Photodynamic Therapy (PDT) is a very exciting treatment modality that offers the possibility of a highly targeted treatment for cancer and other diseases. A major issue in the use of PDT is the inability to deliver the required dose of light to deep areas of the tumor. The turbid nature of tissue causes the light to be highly scattered before reaching the base of the tumor. In this paper, we first present the basics of PDT for an interdisciplinary audience only vaguely familiar with PDT. We will then examine the use of a complex adaptive system to increase the penetration depth and control of light in the tissue. By using a feedback mechanism, the light path can be adjusted to yield superior illumination within the tissue.