EVALUATION OF THE GENOTOXIC EFFECT OF NONYLPHENOL APPLIED IN DIFFERENT DOSES ON THE BONE MARROW

Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. In this study, 5 groups were formed from 50 Wistar albino adult male rats. Groups were classified as control group, the sham administered only (150 µl) group, low dose (25 µl / 125 µl sham), medium dose (50 µl / 100 µl sham) and high dose (75 µl / 75 µl sham) nonylphenol administered group. After 24 hours, the rats were euthanized and analyzed to detect DNA damage by determining the polychromatic erythrocyte/Normochromatic erythrocyte ratio and the number of micronucleated polychromatic erythrocytes in the femur bone marrow cells. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control (p=0.0002, p