[性激素影响下血管壁肌细胞酶组织化学变化]。

M Khristova
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引用次数: 0

摘要

Wistar品系雌性大鼠分别给予雌二醇、孕酮和睾酮三次注射。分别在门静脉、后腔静脉和主动脉壁上观察心肌细胞的变化。组织化学方法显示细胞内以厌氧氧化为主的脱氢酶分布。在给动物注射睾酮后,它们的活性增加,而在注射黄体酮后,它们的活性降低。腺苷-3磷酸酶活性在雌二醇治疗后升高,在黄体酮治疗后降低。门静脉纵肌层部分酶活性较圆肌层表现得更好,这与门静脉纵肌层功能负荷较大有关。动脉和静脉肌细胞的酶组织化学变化动力学在很大程度上相似。
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[Enzyme histochemical changes in the myocytes of the vascular wall under the influence of sex hormones].

Estradiol, progesterone and testosterone were administered three times in the female rats of Wistar strain. Myocytes were studied in the wall of the portal vena, posterior vena cava and aorta. The used histochemical methods showed distribution of dehydrogenases, which was characteristic of predominating anaerobic oxidation in cells. They increased their activity after animals were treated with testosterone and they reduced it after treatment with progesterone. Adenosin-3-phosphatase activity was increased after administration of estradiol and was reduced after treatment with progesterone. Better manifested activity of some enzymes in the longitudinal muscular layer of the portal vena in comparison with circular layer was connected with greater functional loading of this layer. It was found to a great extent similarity in dynamics of enzyme histochemical changes in arterial and venous myocytes.

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