硫化物疗法对营养和再生状态影响的实验和临床证据:一项基本的随机对照试验

V. E. Vladimirskiy, F. M. Hassaballa, E. V. Vladimirskiy, Natalia I. Gulyaeva
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介绍。对于合并高血压(AH)和前驱糖尿病等合并症患者的治疗策略,除推荐药物外,还广泛采用非药物治疗方法。在大鼠实验和AH及前驱糖尿病患者临床研究的条件下,评价硫化物疗法对脂肪分布和体液状态的影响。材料和方法。本研究具有临床和实验性质,分为实验和临床两个阶段。实验研究是在肥胖的非纯种大鼠身上进行的。动物暴露于硫化物浴和硫化物应用和浴的组合中。在研究的临床阶段,包括AH和前驱糖尿病患者。本研究纳入的所有患者均按照临床指南进行标准化药物治疗,观察组患者在此基础上加用联合硫化物疗法(苏旭湖硫化物涂抹加沐浴),疗程14天。研究计划包括评估体重、腰围(WC)、体重指数(BMI)、评估血清血管内皮生长因子(VEGF)浓度;组织生长因子(TGF b)、胰岛素、瘦素,以及心外膜脂肪厚度(EFT)测定。结果和讨论。实验条件显示脂肪细胞(网膜)发生脂肪分解,心脏所有区域的毛细血管数量增加,CD34表达增加。临床阶段的研究结果表明,脂肪库的重新分配与硫化物疗法的背景。两组患者的体重和BMI动态差异无统计学意义,但治疗组患者的OT和TEF显著降低,HEFR浓度、瘦素显著降低,TEFR β显著升高。实验和临床研究证实了硫化物疗法具有溶脂、再生和调节脂肪因子的作用。
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Experimental And Clinical Evidence of the Sulfide Balneotherapy Influence Efficacy on the Trophological and Regenerative Status: a Fundamental, Randomized Controlled Trial
INTRODUCTION. The therapeutic strategies for managing patients with comorbid conditions, such as arterial hypertension (AH) and prediabetes, are widely adopting non-drug methods along with the recommended medications. AIM. To evaluate the effect on fat distribution and humoral status of sulfide balneotherapy in the conditions of the experiment on white rats and clinical study of AH and prediabetes patients. MATERIAL AND METHODS. The study was of a clinical and experimental nature and consisted of 2 phases – experimental and clinical. The experimental study was carried out on obese, non-pedigreed white rats. Animals were exposed to sulfide baths and a combination of sulfide applications and baths. In the clinical phase of the study, patients with AH and prediabetes were included. All patients included in the present study received standardised drug therapy according to clinical guidelines, and patients in the observation group additionally received combined sulphide balneotherapy (Suksun lake sulphide applications and baths) for 14 days. The study program included assessment of weight, waist circumference (WC), body mass index (BMI), assessment of serum concentrations of vascular endothelial growth factor (VEGF); tissue growth factor (TGF b), insulin and leptin, as well as determination of epicardial fat thickness (EFT). RESULTS AND DISCUSSION. The experimental conditions revealed lipolysis in adipocytes (omentum), as well as an increase in the number of hemocapillaries in all areas of the heart and the growth of CD34 expression. The results of the clinical stage of the study suggest redistribution of fat depots against the background of sulfide balneotherapy. There were no statistically significant differences in weight and BMI in the dynamics, but there was a significant decrease in OT and TEF in the group of patients who received balneotherapy, who also had a significant decrease in HEFR concentration, leptin and an increase in TEFR beta 1. CONCLUSION. The presence of lipolytic, regenerative and adipokine-regulating effects of sulfide balneotherapy was demonstrated in the experiment and clinical study.
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