术前放疗对早期声门上癌喉保护的价值。

F G Fedok, M Strauss, J Stryker
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引用次数: 0

摘要

本研究是对1976年至1986年间12例T1(1)和T2(11) NO声门上癌患者的回顾性研究,这些患者采用计划术前放疗(45-51 Gy)对原发颈部和双侧颈部进行治疗。如果喉镜检查发现肿瘤有足够的反应(体积缩小75%以上),则在65-70 Gy的水平下完成治疗。如果肿瘤反应较小,则行声门上喉切除术。6例患者完成了首次放疗(RT-RT), 6例患者接受了声门上喉切除术(RT-SG)。6例RT-SG患者中有3例肿瘤残留。所有部位均无肿瘤复发。所有患者均保留喉功能。67个月时的绝对生存率为58%。这种方法在肿瘤学上是合理的,并能最大限度地保护喉部。
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The value of preoperative radiotherapy response to maximizing laryngeal conservation in early stage supraglottic carcinoma.

This study is a retrospective review between 1976 and 1986 of 12 patients with T1(1) and T2(11) NO supraglottic cancers which were managed by a method that utilized planned preoperative radiotherapy (45-51 Gy) to the primary and bilateral necks. If adequate tumor response (greater than 75% reduction in size) was noted by laryngoscopy, therapy was completed at levels of 65-70 Gy to the primary. If a lesser tumor response was noted, the patient underwent supraglottic laryngectomy. Six patients completed primary radiotherapy (RT-RT) and six patients underwent supraglottic laryngectomy (RT-SG). There was evidence of residual tumor in three of six RT-SG patients. No tumor recurred at any site. Laryngeal function was preserved in all patients. Absolute survival was 58% at 67 months. This approach is oncologically sound and permits maximal laryngeal conservation.

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