受体光化学处理对大鼠心脏和肾脏移植排斥反应的抑制作用。

H Oesterwitz, S Gruner, W Schneider
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引用次数: 0

摘要

经移植后短暂的PUVA处理后,大鼠同种异体心脏和肾脏移植存活时间明显延长。在半同种异体F1模型中,所有肾移植受者均存活,无排斥反应。目前尚不清楚其作用机制,特别是顺式尿酸的作用,并对该方法在临床器官移植中的应用进行了探讨。
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[Inhibition of rat heart and kidney allograft rejection by photochemical treatment of the recipient].

After temporary posttransplant PUVA treatment of graft recipients the survival time of rat heart and kidney allografts was significantly prolonged. In the semiallogeneic F1 model all kidney transplant recipients survived without rejection signs. The mechanism of action should be cleared especially the role of cis-urocanic acid and the introduction of the method into clinical organ transplantation is discussed.

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