{"title":"栀子叶提取物对乳腺癌大鼠肿瘤细胞增殖的影响","authors":"Ratna Widayati, Yan Wisnu Prajoko, Udadi Sadhana","doi":"10.29303/jku.v10i4.545","DOIUrl":null,"url":null,"abstract":"Background : Immunotherapy is widely used to increase the response rate of chemotherapy drugs. Eleuhterine palmifolia (L) Merr or dayak onion are known to contain phytochemical compounds that have antiproliferative effects, and have been used as anti-cancer empirical therapies. This study aimed to prove the antiproliferative effect of Eleuhterine palmifolia (L) Merr extract in Sprague-Dawley rats with breast cancer. \nMethods : This study used 18 Sprague-dawley rats, divided into 3 groups, K, P1 and P2. K was given regular feed, P1 received adriamycin 5 mg/kgBW single dose, P2 received adriamycin 5 mg/kgBW single dose and extract of dayak onion 105 mg/kgBW/day for 3 weeks. \nResults : Difference in tumor size before and after treatment was 7.2 ± 2.57 mm (K), 3.23 ± 3.03 mm (P1), 3.14 ± 2.65 mm (P2), with p value is 0,157 (p>0,05). Ki-67 index calculations are 11.1 ± 7.27% (K), 9.64 ± 6.99% (P1), 9.58 ± 3.52% (P2), with p value is 0,704 (p>0,05). \nConclusion : The addition of Eleuhterine palmifolia (L) Merr (dayak onion) extract did not cause a significant difference in tumor cell proliferation in Sprague-Dawley rats with breast cancer.","PeriodicalId":135675,"journal":{"name":"Unram Medical Journal","volume":"73 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EFFECT OF ELEUHTERINE PALMIFOLIA (L) MERR ON TUMOR CELL PROLIFERATION IN SPRAGUE DAWLEY RATS WITH BREAST CANCER\",\"authors\":\"Ratna Widayati, Yan Wisnu Prajoko, Udadi Sadhana\",\"doi\":\"10.29303/jku.v10i4.545\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background : Immunotherapy is widely used to increase the response rate of chemotherapy drugs. Eleuhterine palmifolia (L) Merr or dayak onion are known to contain phytochemical compounds that have antiproliferative effects, and have been used as anti-cancer empirical therapies. This study aimed to prove the antiproliferative effect of Eleuhterine palmifolia (L) Merr extract in Sprague-Dawley rats with breast cancer. \\nMethods : This study used 18 Sprague-dawley rats, divided into 3 groups, K, P1 and P2. K was given regular feed, P1 received adriamycin 5 mg/kgBW single dose, P2 received adriamycin 5 mg/kgBW single dose and extract of dayak onion 105 mg/kgBW/day for 3 weeks. \\nResults : Difference in tumor size before and after treatment was 7.2 ± 2.57 mm (K), 3.23 ± 3.03 mm (P1), 3.14 ± 2.65 mm (P2), with p value is 0,157 (p>0,05). Ki-67 index calculations are 11.1 ± 7.27% (K), 9.64 ± 6.99% (P1), 9.58 ± 3.52% (P2), with p value is 0,704 (p>0,05). \\nConclusion : The addition of Eleuhterine palmifolia (L) Merr (dayak onion) extract did not cause a significant difference in tumor cell proliferation in Sprague-Dawley rats with breast cancer.\",\"PeriodicalId\":135675,\"journal\":{\"name\":\"Unram Medical Journal\",\"volume\":\"73 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Unram Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29303/jku.v10i4.545\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Unram Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29303/jku.v10i4.545","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:免疫治疗被广泛用于提高化疗药物的应答率。众所周知，刺叶椰子树(L)或大葱含有具有抗增殖作用的植物化学化合物，并已被用作抗癌经验疗法。本研究旨在证明刺白叶提取物对Sprague-Dawley乳腺癌大鼠的抗增殖作用。方法:选取18只Sprague-dawley大鼠，分为K、P1、P2 3组。K给予常规饲料，P1给予阿霉素5 mg/kgBW单次剂量，P2给予阿霉素5 mg/kgBW单次剂量和大葱提取物105 mg/kgBW/d，连续3周。结果:治疗前后肿瘤大小差值分别为7.2±2.57 mm (K)、3.23±3.03 mm (P1)、3.14±2.65 mm (P2)， p值为0.157 (p < 0.05)。Ki-67指数计算值分别为11.1±7.27% (K)、9.64±6.99% (P1)、9.58±3.52% (P2)， p值为0.704 (p < 0.05)。结论:在Sprague-Dawley大鼠乳腺癌模型中，添加刺叶葱提取物对肿瘤细胞增殖无显著影响。
EFFECT OF ELEUHTERINE PALMIFOLIA (L) MERR ON TUMOR CELL PROLIFERATION IN SPRAGUE DAWLEY RATS WITH BREAST CANCER
Background : Immunotherapy is widely used to increase the response rate of chemotherapy drugs. Eleuhterine palmifolia (L) Merr or dayak onion are known to contain phytochemical compounds that have antiproliferative effects, and have been used as anti-cancer empirical therapies. This study aimed to prove the antiproliferative effect of Eleuhterine palmifolia (L) Merr extract in Sprague-Dawley rats with breast cancer.
Methods : This study used 18 Sprague-dawley rats, divided into 3 groups, K, P1 and P2. K was given regular feed, P1 received adriamycin 5 mg/kgBW single dose, P2 received adriamycin 5 mg/kgBW single dose and extract of dayak onion 105 mg/kgBW/day for 3 weeks.
Results : Difference in tumor size before and after treatment was 7.2 ± 2.57 mm (K), 3.23 ± 3.03 mm (P1), 3.14 ± 2.65 mm (P2), with p value is 0,157 (p>0,05). Ki-67 index calculations are 11.1 ± 7.27% (K), 9.64 ± 6.99% (P1), 9.58 ± 3.52% (P2), with p value is 0,704 (p>0,05).
Conclusion : The addition of Eleuhterine palmifolia (L) Merr (dayak onion) extract did not cause a significant difference in tumor cell proliferation in Sprague-Dawley rats with breast cancer.
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