Correlation of βhCG Levels with Size of Gestational Sac in Patients of Ectopic Pregnancy Presenting to a Tertiary Care Health Facility

Abstract:The objective of this study was to determine correlation of β- HCG levels with size of gestational sac in patients of ectopic pregnancy presenting to a tertiary care health facility. Materials and Methods: This descriptive cross-sectional study was carried out in the Department of Obstetrics and Gynecology, district headquarter Hospital, Rawalpindi from Jan 2019 to Jan 2020. This study involved 100 pregnant women aged between 20-40 years diagnosed of ectopic pregnancy on transvaginal ultrasound. Serum βhCG level was acquired in all these women while the size of gestational sac was measured on transvaginal ultrasound. Outcome variable was correlation between serum βhCG level and size of gestational sac on transvaginal ultrasound which was noted and compared across various subgroups of patients based on age, gestational age, site of ectopic pregnancy and presence/absence of fetal cardiac activity. Results: The mean age of the patients was 29.3±6.1 years while the mean gestational age was 5.1±1.1 weeks. Serum βhCG level ranged from 1647 mIU/mL to 18378 mIU/mL with a mean of 7968.4±4523.7 mIU/mL while the size of gestational sac on TVS ranged from 17 mm3 to 45 mm3 with a mean of 36.40±7.86 mm3. There was significantly strong positive correlation between serum βhCG and size of gestational sac on TVS (r=0.659; p- value<0.001). Conclusion: There was significantly strong positive correlation between serum βhCG and size of gestational sac on TVS (r=0.659; p-value<0.001).