钙诱导心脏损伤的跨壁非均匀性。

Physiologia Bohemoslovaca Pub Date : 1990-01-01
N Tribulová, J Slezák, T Ravingerová, A Ziegelhöffer
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引用次数: 0

摘要

Ca悖论导致心肌心外膜下层组织化学研究的酶活性(SDH、LDH、β - hbdh、磷酸化酶和atp酶)明显抑制,甚至消失。在心内膜下区域,仅略有下降。这些跨壁差异与超微结构变化密切相关。假设损伤跨壁分布的异质性是冠状动脉血流跨壁差异的结果。
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Transmural non-homogeneity of calcium-induced heart injury.

The Ca paradox resulted in marked inhibition, up to disappearance, of histochemically studied enzyme activities (SDH, LDH, beta-HBDH, phosphorylase and ATPase) in the subepicardial layer of the myocardium. In the subendocardial region there was only a small decrease. These transmural differences correlated well with ultrastructural changes. It is assumed that the heterogeneity in transmural distribution of injury is the result of transmural differences in coronary flow.

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