A G D'iachenko, I G Kondzhariia, E V Indzhiia, B A Lapin, L A Iakovleva, L D Rudaia, B L Dzhalagoniia
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[Monoclonal integration of simian T-cell leukemia virus in hamadryas with malignant lymphoma].
The association of simian T-cell leukemia virus with baboons malignant lymphoma was studied. Proviral DNA integrated in cells of lymphoid organs was detected in 19 of 21 sick animals examined. Only 4 of 10 monkeys from high risk colony without clinical manifestations had virus-specific sequences in their cellular DNAs. As a rule, S(H)TLV-I-infected cells monoclonally proliferated both in lymphomatous and healthy baboons. The restriction patterns with EcoRI, HindIII, PstI, BamHI of S(H)TLV-I provirus were similar but not identical to those of prototype HTLV-I and STLV-I isolates.
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