[金属的遗传毒性和致癌作用特点]。

Eksperimental'naia onkologiia Pub Date : 1990-01-01

T P Maksimchuk, G A Babenko

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引用次数: 0

摘要

综述了某些金属及其化合物对人类和实验动物的致癌活性数据。描述了不同短期试验中金属化合物的细胞摄取和细胞内分布、金属诱导的遗传毒性。正在讨论致癌金属对DNA产生的特殊损害、金属离子对细胞生长的影响、涉及突变和肿瘤发生的DNA复制和DNA修复。与有机致癌机制相比，金属致癌机制的研究较少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Characteristics of genotoxic and carcinogenic action of metals].

The data on carcinogenic activity of certain metals and their compounds to humans and experimental animals are reviewed. Cellular uptake and intracellular distribution of metal compounds, metal-induced genotoxicity in different short-term tests are described. Specific lesions of DNA produced by carcinogenic metals, the influence of metal ions on the cell growth, DNA replication and DNA repair involved in mutagenesis and oncogenesis are under discussion. Mechanisms of metal carcinogenesis are studied to a less extent as compared with organic carcinogenesis.

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Eksperimental'naia onkologiia

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