Abscopal effects induced by localized interventions in oncological patients.

© 2021 Annals of Research in Oncology ARO. Published by EDRA SpA. All rights reserved. ABSTRACT Abscopal, or out-of-fields effects were reported among a number of oncological patients, who were treated with radiation therapy in combination with immune checkpoints inhibitors. The radiations induce a localized immunogenic cell death within the malignant tissues of the irradiated area. Necro-apoptotic cancer cells, in turn, stimulate tumor-specific immune responses in oncological patients, who were previously treated with immune checkpoints inhibitors. Consequently, the host immune system is able to target 1 College of Science and Technology, Temple University, Philadelphia, PA, USA 2 Sbarro Health Research Organization, Philadelphia, PA, USA