[补充纤维蛋白胶密封后结肠吻合口稳定性的实验动物研究]。

R Elfeldt, D Leuze, A Thiede, J Seifert
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引用次数: 0

摘要

结肠的缝合线可能不足或漏缝。这在某些情况下会导致腹膜炎或败血症,有时会导致致命的后果。因此,我们进行了动物实验来研究外加生物源胶的效果。特别是在创面愈合初期,术后第4天,纤维蛋白胶可提高创面的硬度。纤维蛋白胶密封结肠缝合线破裂压力为94 mmHg,而对照组仅为66 mmHg。这种额外的坚固性在整个3周的观察时间内保持不变。结缔组织的增殖加剧是造成这一观察结果的原因,这可以通过组织学调查和测量疤痕的厚度来证实。如果在动物身上使用生物胶,可能会导致受体产生抗体,因为这种胶的成分是来自不同物种的蛋白质。对经纤维蛋白胶处理的动物血清的调查显示,部分动物血清中沉淀出抗纤维蛋白原的抗体。关于这一观察,必须采取必要的预防措施进行生物胶的第二次应用。
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[Experimental animal studies of the stability of colon anastomoses after supplementary fibrin glue sealing].

Sutures of the colon can be insufficient or leaking. This leads in some cases to a peritonitis or sepsis sometimes with lethal outcome. Therefore experiments in animals were performed to investigate the effect of additional applied biogenic glue. Especially in the beginning of the wound healing, at the 4th postoperative day, the firmness could be improved by fibrin glue. The bursting pressure of fibrin glue sealed colon sutures was 94 mmHg, whereas only 66 mmHg was observed in the control group. This additional firmness remains over the whole observation time of 3 weeks. An intensified proliferation of the connective tissue is responsible for this observation which could be substantiated by histological investigations and by measuring the thickness of the scar. If biogenic glue is used in animals it can have the consequence that the recipient reacts with the production of antibodies, since the components of the glue are proteins from different species. Investigations of the serum of animals which had been treated with fibrin glue revealed in a part of them precipitating antibodies against fibrinogen. With regard to this observation a second application of biogenic glue must be done with the necessary precaution.

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