肺癌分类工具使用微阵列数据和支持向量机

J. Cabrera, Abigaile Dionisio, Geoffrey A. Solano
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引用次数: 17

摘要

肺癌是世界上最致命的癌症之一。流行病学研究表明,遗传变异是影响一个人对肺癌易感性的因素之一。最近,美国国立癌症研究所的研究小组以1.4万名亚洲女性为对象进行的一项研究发现,无论吸烟与否,亚洲女性由于基因变异更容易患癌症。本研究提出了一个系统,利用来自寡核苷酸微阵列的基因表达数据来预测肺癌的存在或不存在,预测肺癌的特定类型,并确定可归因于特定类型疾病的标记基因。所提出的系统将有助于更快的诊断,并作为现有肺癌分类方法的可靠辅助方法。
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Lung cancer classification tool using microarray data and support vector machines
Lung cancer is one of the deadliest types of cancer around the world. Epidemiologic studies have shown that genetic variability is among the factors that affect a person's susceptibility to lung cancer. A recent study conducted by a team of researchers from the United States National Cancer Institute among 14,000 Asian women found out that Asian women, whether smokers or not, are more prone to developing cancer due to their genetic variations. This study proposes a system that utilizes gene expression data from oligonucleotide microarrays to predict the presence or absence of lung cancer, predict the specific type of lung cancer should it be present, and determine marker genes that are attributable to the specific kind of the disease. The proposed system would help in the faster diagnosis and serve as a reliable adjunct approach to current lung cancer classification methods.
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