The features of clinical manifestations of acute stroke associated with COVID-19

The most severe course of COVID-19 is observed in patients with vascular comorbidity (more than 3 cardiovascular diseases). At the same time, a large number of complications from various organs and systems are recorded in this group of patients, with acute stroke being one of the most severe. Stroke in patients with COVID-19 is characterized by a severe clinical course, with a high rate of deaths and poor rehabilitation prognosis in the early and late recovery period. The cohort combined retrospective-prospective study included 80 patients. All subjects were divided into groups: 1) patients with stroke and COVID-19; 2) stroke patients without COVID-19; 3) COVID-19 patients without stroke. All patients underwent complex clinical and laboratory monitoring, including general and biochemical blood tests, assessment of hemostasis and the level of pro-inflammatory cytokines, and MSCT of the brain and lungs. As a result of the study, it was found that patients with stroke and COVID-19 have a more severe course of the disease with a high incidence of multiple organ dysfunction syndrome (MODS) and deaths at the hospital stage.