[脉络膜黑色素瘤放疗引起的黄斑病变]。

C Haye, L Desjardins, P Bouder, P Schlienger, T Dorval
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引用次数: 0

摘要

自1968年以来,我们一直在居里研究所使用钴60斑块治疗恶性脉络膜黑色素瘤。我们回顾了1982年至1984年间接受治疗的79例患者,随访时间最短为5年。肿瘤厚度在2 ~ 11mm之间,平均厚度为5.7 mm。所有肿瘤顶点处至少有70个灰色。7例患者因其他原因死亡,7例患者出现转移,65例患者生存良好,其中49例保留眼睛,16例已去核。18例因严重黄斑病变视力低于20/200,29例视力在20/200 ~ 20/25之间。最严重的功能性视力丧失是由于黄斑病变。主要表现为毛细血管阻塞、渗出和囊样黄斑水肿。如果我们将这些结果与其他作者的结果进行比较,我们会发现黄斑病变是钴60的常见问题。由于这些原因,我们打算在未来使用碘125斑块和原治疗,应该会给我们更好的功能效果。
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[Maculopathy caused by irradiation in patients treated for choroid melanoma].

We are using Cobalt 60 plaques at Curie Institute since 1968 for the treatment of malignant choroidal melanoma. We reviewed a series of 79 patients treated between 1982 and 1984 with a minimal follow up of 5 years. Tumors thickness varies between 2 and 11 mm with a mean thickness of 5.7 mm. All the tumors received at least 70 grays at the apex. 7 patients died from other cause, 7 patients presented metastasis 65 patients are alive and well, 49 of them have kept their eye and 16 have been enucleated. 18 patients have a visual acuity below 20/200 because of severe maculopathy, 29 patients have a visual acuity between 20/200 and 20/25. The most severe functional visual loss was due to maculopathy. It consisted of obliteration of the capillaries, exsudation and cystoid macular oedema. If we compare these results to other authors we see that maculopathy is a frequent problem with cobalt 60. For these reasons, we intend in the future to use iodine 125 plaques and prothontherapie that should give us better functional results.

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