A Review on Remdesivir: A Probable Cure for Covid-19

The current scenario of the world is very critical as there is a global Pandemic of COVID-19 looming around in the world. It has claimed lives of millions of people and has adversely affected the health of millions. COVID-19 is an infectious disease caused by the novel corona virus. This disease is highly contagious in nature and hence it was regarded as the global pandemic by World Health Organization. There are many researches going on to either find a vaccine or find a cure for this deadly disease. Remdesivir is one such medicine which is proposed to be a probable cure for COVID-19. This medicine proved effective in the past for treatment of the ebola virus infection and the Middle East respiratory syndrome (MERS) infection; due to this researches on this medicine to be a potential cure were done. In a number of researches done in this area it was found that when remdesivir was administered to the infected individuals the recovery rate of the infected people was faster when they were given this medicine as compared to those who were not. This paper discusses about the medicine remdesivir in detail; from its discovery, functioning in human body to its chemical composition. The researches done and the clinical results of the medicines are also discussed which all point in the direction that this medicine could pose to be an aid in curing the corona virus disease. anti-viral research these any viruses coronavirus and even some of the viruses of flaviviridae family dengue and zika virus. Clinical Studies: Various clinical studies have been carried out on the remdesivir drug to prove its efficiency and potential in treating diseases like COVID-19. Also such studies depict any side-effects from such drugs. Some of these studies are mentioned below. It has been seen that the in vitro and in vivo animal models have been proved useful in proving the effectiveness of remdesivir against SARS-CoV-2 and other similar coronaviruses. A recent in vitro study was conducted on remdesivir drug to measure the antiviral activity against SARS-CoV2. This study aimed to depict an IC 50 of 770 nM and an IC 90 equal to 1,760 nM along with the cytotoxic concentration of more than 100 mM. [15] Along with this another study conducted by Sheahan et al . and De Wit et al . illustrated that Remdesivir had the enough potential in halting the replication and reducing viral pathology against such Coronaviruses. This study showcased in vivo efficacy of Remdesivir. Such studies along with the safety profile of Remdesivir in the clinical trials against Ebolavirus aid in the assessment of remdesivir as a potential therapeutic drug for reducing effects of SARS-CoV-2 I this current pandemic outbreak. [16] In the study it was found that remdesivir drug showed huge in vitro anti-viral activity against zoonotic and human pathogens coming from families of various viruses. However the anti-viral activity of this drug has consistent results when studied against Filoviridae, Coronaviridae, Pneumoviridae and virus family. Remdesivir contains three HCoV strains linked with respiratory illness also other types