[肾移植术后患者白细胞介素1-和白细胞介素2测定的临床价值]。

Allergie und Immunologie Pub Date : 1990-01-01
S Buchwald, H Friemel, A Plantikow, B Hudemann, R Bast, R Templin
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引用次数: 0

摘要

在一项对肾移植受者同种异体移植排斥反应的回顾性研究中,我们检查了细胞因子产生监测的价值。在肾移植后60天内,连续测定8例肾移植受者有丝分裂原刺激的外周血淋巴细胞上清液中白细胞介素1 (IL 1)和白细胞介素2 (IL 2)的活性。与健康对照相比,肾移植后患者lps诱导的IL - 1和pha诱导的IL - 2产生显著降低。在此期间,在肾移植受者中诊断出7次细胞排斥反应,然而,只有4次排斥反应与IL - 1升高和同时IL - 2产生有关,发生在排斥反应诊断前的2至3天。此外,有12例IL - 1和IL - 2的升高与排斥反应无关。8例IL - 1和IL - 2的增加可能与临床感染有关。我们从这些结果中得出结论,细胞因子监测对同种异体移植排斥的诊断似乎并不有用。
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[Clinical value of interleukin 1- and interleukin 2-determinations in patients after kidney transplantation].

In a retrospective study of allograft rejections in renal transplant recipients we examined the value of cytokine production monitoring. Interleukin 1 (IL 1) and interleukin 2 (IL 2) activities were determined in supernatants of mitogen-stimulated peripheral blood lymphocytes in 8 renal transplant recipients serially for a period up to 60 days after transplantation. LPS-induced IL 1 as well as PHA-induced IL 2 production in patients after renal transplantation were significantly decreased in comparison to healthy controls. Seven episodes of cellular rejection were diagnosed in renal allograft recipients during this time, only 4 rejection episodes, however, were associated with a rise in the IL 1 and simultaneous IL 2 production occurred for 2 up to 3 days before the diagnosis of rejection. Moreover there were 12 instances in which an elevation of IL 1 and IL 2 production was found independently from the rejection. In 8 cases the augmentation of IL 1 and IL 2 production could be associated with clinical infections. We conclude from these results that a cytokine monitoring for the diagnosis of allograft rejection does not seem to be useful.

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