面向即时血液学诊断的片上血液粘度计

H. Zeng, Y. Zhao
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引用次数: 10

摘要

血液粘度是一项重要的血液学参数,广泛用于动脉粥样硬化、血栓形成和脑卒中的诊断。目前使用的Couette流变仪以一定的剪切速率驱动血液流动,并测量从阻力转矩到旋转轴的粘度。传统流变仪虽然有效,但由于结构复杂和样品量较大,受到了限制。更重要的是,旋转组件阻碍了点护理和无人值守诊断的小型化。为了解决这个问题,据报道,一种微芯片可以通过在微通道内流动的血液的电阻抗来测量血液粘度。与旋转粘度计相比,该微装置具有样品消耗少、响应快、配置简单等优点。考虑到血液粘度在心血管疾病中的重要作用,该微芯片为片上血液学诊断提供了一个有希望的起点。
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On-Chip Blood Viscometer Towards Point-of-Care Hematological Diagnosis
Blood viscosity is an important hematological parameter which is widely used for the diagnosis of atherosclerosis, thrombosis and stroke. Currently used Couette rheometer drives the blood flow at a certain shear rate and measures the viscosity from the resistance toque towards the rotational shaft. Although effective, conventional rheometer is limited due to the complex configuration and the relatively large sample volume. More important, the rotating components hinder the miniaturization for point-of-care and unattended diagnosis. To address this, a microchip is reported for measuring the blood viscosity from the electrical impedances of the blood flowing inside a microchannel. This microdevice is advantageous over rotational viscometers in less sample consumption, rapid response and simple configuration. Considering the vital role of blood viscosity in cardiovascular disorders, this microchip provides a promising start point for on-chip hematological diagnosis.
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