{"title":"利用离子迁移的MALDI-Q-TOF/MS成像技术增强了黄芩代谢物的识别和定位","authors":"Lixing Nie, Lieyan Huang, Xiaofei Jia, Shuai Kang, Lingwen Yao, Yanpei Wu, Hao Yuan, Yongli Liu, Feng Wei, Hongyu Jin, Xiang Li, Shuangcheng Ma","doi":"10.1016/j.jpha.2023.09.018","DOIUrl":null,"url":null,"abstract":"• MALDI-IM-MS localization of metabolites in Scutellariae Radix was conducted for the first time. • Mobility- m / z plot offered distinct separation of endogenous metabolites from matrix. • Exclusive trend line enabled more selective characterization of flavonoids.","PeriodicalId":16737,"journal":{"name":"Journal of Pharmaceutical Analysis","volume":"2014 1","pages":"0"},"PeriodicalIF":6.1000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled MALDI-Q-TOF/MS imaging\",\"authors\":\"Lixing Nie, Lieyan Huang, Xiaofei Jia, Shuai Kang, Lingwen Yao, Yanpei Wu, Hao Yuan, Yongli Liu, Feng Wei, Hongyu Jin, Xiang Li, Shuangcheng Ma\",\"doi\":\"10.1016/j.jpha.2023.09.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"• MALDI-IM-MS localization of metabolites in Scutellariae Radix was conducted for the first time. • Mobility- m / z plot offered distinct separation of endogenous metabolites from matrix. • Exclusive trend line enabled more selective characterization of flavonoids.\",\"PeriodicalId\":16737,\"journal\":{\"name\":\"Journal of Pharmaceutical Analysis\",\"volume\":\"2014 1\",\"pages\":\"0\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Analysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jpha.2023.09.018\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jpha.2023.09.018","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
•首次对黄芩中代谢物进行了MALDI-IM-MS定位。•迁移率- m / z图显示了内源代谢物与基质的明显分离。•独有的趋势线使黄酮类化合物的表征更具选择性。
Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled MALDI-Q-TOF/MS imaging
• MALDI-IM-MS localization of metabolites in Scutellariae Radix was conducted for the first time. • Mobility- m / z plot offered distinct separation of endogenous metabolites from matrix. • Exclusive trend line enabled more selective characterization of flavonoids.
期刊介绍：
The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University.
JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.
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