Mali Kalpana Ramanna, Soundarya Priyadarsini. K, Siddharam S. Janti, Maduram Annamalai, Madhavi Eerike
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To compare the effect of ethanolic extract of Manilkara zapota seeds with the commonly used analgesic drug aspirin. Material and Methods: This study was conducted by using Eddy's hot plate method. A total of 12 Adult Wistar albino rats were grouped into three groups of 4 animals in each group. These groups were Group I: Control (normal saline), Group II: Standard (Aspirin 25mg per kg) Group III: Ethanolic extract of Manilkara zapota (200mg per kg). The reaction time was recorded at 0, 30, 60 & 90 minutes after injecting normal saline, standard drug, and extract. Result: The increase in mean reaction time of the extract was statistically significant (p< 0.0001) at 30, 60, and 90 min compared to that of the control. There was less increase in the reaction time of extract treated group compared to that of the aspirin-treated group at 30 min & 60 min points. Conclusion: The analgesic activity of the extract was significantly more than that of the control group. Peak analgesic activity occurred at 60 and 90 minutes.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the Analgesic Activity of Ethanolic Extract of Manilkara Zapota Seeds in Experimental Animal Model\",\"authors\":\"Mali Kalpana Ramanna, Soundarya Priyadarsini. K, Siddharam S. Janti, Maduram Annamalai, Madhavi Eerike\",\"doi\":\"10.13005/bpj/2759\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Non-Steroidal Anti-Inflammatory Drugs and opioids use remain the mainstay for pain treatment. However, both groups of drugs are well known for their common and severe side effects. Medicinal plants could be the better option to overcome these side effects. 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The reaction time was recorded at 0, 30, 60 & 90 minutes after injecting normal saline, standard drug, and extract. Result: The increase in mean reaction time of the extract was statistically significant (p< 0.0001) at 30, 60, and 90 min compared to that of the control. There was less increase in the reaction time of extract treated group compared to that of the aspirin-treated group at 30 min & 60 min points. Conclusion: The analgesic activity of the extract was significantly more than that of the control group. 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引用次数: 0
摘要
非甾体类抗炎药和阿片类药物仍然是治疗疼痛的主要方法。然而,这两组药物都以其常见和严重的副作用而闻名。药用植物可能是克服这些副作用的更好选择。芒果树种子的抗炎活性已在实验动物中得到证实。由于疼痛总是伴随着炎症,我们采用Eddy's hot plate法对动物模型进行了一项研究,以发现芒草乙醇提取物的镇痛活性。目的与目的:采用热板法研究芒草种子乙醇提取物的镇痛作用。比较芒草种子乙醇提取物与常用镇痛药阿司匹林的镇痛效果。材料与方法:本研究采用涡流热板法。取成年Wistar白化大鼠12只,随机分为3组,每组4只。各组分别为:ⅰ组:对照组(生理盐水),ⅱ组:标准组(阿司匹林25mg / kg),ⅲ组:芒草乙醇提取物(200mg / kg)。反应时间分别记录在0、30、60安培;注射生理盐水,标准药物和提取物90分钟后。结果:提取液的平均反应时间增加有统计学意义(p<0.0001)在30,60和90分钟与对照组相比。在30 min时,提取物处理组的反应时间较阿司匹林处理组增加较少;60分。结论:该提取物的镇痛活性明显高于对照组。镇痛活性峰值出现在60分钟和90分钟。
Evaluation of the Analgesic Activity of Ethanolic Extract of Manilkara Zapota Seeds in Experimental Animal Model
Introduction: Non-Steroidal Anti-Inflammatory Drugs and opioids use remain the mainstay for pain treatment. However, both groups of drugs are well known for their common and severe side effects. Medicinal plants could be the better option to overcome these side effects. The anti-inflammatory activity of seeds of Manilkara zapota has already been demonstrated in experimental animals. As pain always accompanies inflammation, we have set forward a study to discover the analgesic activity of the ethanolic extract of Manilkara Zapota in animal models using Eddy's hot plate method. Aims and objectives: To explore the analgesic activity of ethanolic extract of Manilkara zapota seeds using Eddy's hot plate method. To compare the effect of ethanolic extract of Manilkara zapota seeds with the commonly used analgesic drug aspirin. Material and Methods: This study was conducted by using Eddy's hot plate method. A total of 12 Adult Wistar albino rats were grouped into three groups of 4 animals in each group. These groups were Group I: Control (normal saline), Group II: Standard (Aspirin 25mg per kg) Group III: Ethanolic extract of Manilkara zapota (200mg per kg). The reaction time was recorded at 0, 30, 60 & 90 minutes after injecting normal saline, standard drug, and extract. Result: The increase in mean reaction time of the extract was statistically significant (p< 0.0001) at 30, 60, and 90 min compared to that of the control. There was less increase in the reaction time of extract treated group compared to that of the aspirin-treated group at 30 min & 60 min points. Conclusion: The analgesic activity of the extract was significantly more than that of the control group. Peak analgesic activity occurred at 60 and 90 minutes.
期刊介绍:
Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.