Metal Ion Containing Anti-Bacterial Gel: An Overview

The antibacterial properties of metal ions like copper and zinc sulfate have been investigated for skin infections occur commonly and often present therapeutic challenges to researchers due to the growing concerns regarding multidrug-resistant bacterial, viral, and fungal strains. However, the synergistic activity between these two metal ions as antimicrobial ingredients has not been evaluated in topical formulations. Formulation of the gels and creams was followed by evaluating their organoleptic characteristics, physicochemical properties, and in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus. Zinc sulfate and copper sulfate had a strong synergistic antibacterial activity in the creams and gels. In this paper evaluated and confirmed the synergistic in vitro antibacterial effect of copper sulfate and zinc sulfate in a cream and gels.