秋葵黏液作为片剂粘结剂的提取、分离及特性研究

Rutuja R Shah, Rahul S Adnaik, Pratibha R Adnaik, Swapnil S Patil
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引用次数: 0

摘要

本研究的主要目的是提取一种天然聚合物(秋葵粘液)及其作为药物粘合剂的特性,并利用秋葵粘合剂配制、开发和评估片剂的压缩性能。粘合剂是用来赋予颗粒内聚性的药剂。这样可以确保药片在压缩后保持完整。研究人员正在努力寻找新的赋形剂,以潜在地在片剂配方中使用结合剂。这是因为不同的结合剂可用于不同的药物用途,以获得不同的片剂机械强度和药物释放特性。结果表明,从秋葵中提取的黏液可作为对乙酰氨基酚片的粘合剂,具有良好的物理性能。制备了崩解时间较长的片剂,具有结合制备制剂颗粒剂的潜力。
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Extraction, Isolation and Characterization of Okra Mucilage, as Potential source of Binder in Tablet
The major objective of the present investigation was to extract a natural polymer (okra mucilage) with its characterization as a pharmaceutical binder and to formulate, develop and evaluate the compression of tablet using okra binder. Binders are agent employed to impart cohesiveness to the granules. This ensures the tablet remain intact after compression. The researcher is trying to find new excipient for potential use of binding agent in tablet formulation continues to the interest. This is because different binding agent can be useful in achieving various tablet mechanical strength and drug release properties for different pharmaceutical purpose. The result presented here shows that the mucilage obtained from okra can be used as a binder in paracetamol tablets formulation with good physical properties. Tablet of long disintegration times were produced, hence it’s potential in binding and prepare the granule of pharmaceutical formulation.
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