{"title":"依达拉奉治疗脑卒中和颅外病理的新的和鲜为人知的可能性","authors":"O.A. Halushko","doi":"10.32902/2663-0338-2023-3-36-42","DOIUrl":null,"url":null,"abstract":"BACKGROUND. Edaravone is a free radical scavenger and inhibits lipid peroxidation and thus reduces oxidative damage to brain cells and other organs. Edaravone is mainly known as an effective agent in the treatment of ischemic stroke and amyotrophic lateral sclerosis.
 OBJECTIVE. To investigate the little-known possibilities of edaravone when it is used in clinical practice.
 MATERIALS AND METHODS. To solve the task, a search and analysis of full-text articles was conducted in the PubMed, Web of Science, Google Scholar, and Scopus databases. The search was conducted using the key word “edaravone” and included English-language and Ukrainian-language publications over the past 5 years (from April 2018 to April 2023).
 RESULTS. A total of 518 publications were identified and analyzed. Edaravone has been found to improve the clinical course and may be useful in the treatment of central nervous system diseases, depression, post-traumatic stress disorder, cognitive dysfunction, oncological and infectious diseases (in particular, coronavirus disease), many poisonings, etc. All this dictates the need for further clinical studies to explore new and unexpected possibilities of edaravone.","PeriodicalId":13681,"journal":{"name":"Infusion & Chemotherapy","volume":"33 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New and little-known possibilities of edaravone in the treatment of cerebral stroke and extracranial pathology\",\"authors\":\"O.A. Halushko\",\"doi\":\"10.32902/2663-0338-2023-3-36-42\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND. Edaravone is a free radical scavenger and inhibits lipid peroxidation and thus reduces oxidative damage to brain cells and other organs. Edaravone is mainly known as an effective agent in the treatment of ischemic stroke and amyotrophic lateral sclerosis.
 OBJECTIVE. To investigate the little-known possibilities of edaravone when it is used in clinical practice.
 MATERIALS AND METHODS. To solve the task, a search and analysis of full-text articles was conducted in the PubMed, Web of Science, Google Scholar, and Scopus databases. The search was conducted using the key word “edaravone” and included English-language and Ukrainian-language publications over the past 5 years (from April 2018 to April 2023).
 RESULTS. A total of 518 publications were identified and analyzed. Edaravone has been found to improve the clinical course and may be useful in the treatment of central nervous system diseases, depression, post-traumatic stress disorder, cognitive dysfunction, oncological and infectious diseases (in particular, coronavirus disease), many poisonings, etc. All this dictates the need for further clinical studies to explore new and unexpected possibilities of edaravone.\",\"PeriodicalId\":13681,\"journal\":{\"name\":\"Infusion & Chemotherapy\",\"volume\":\"33 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infusion & Chemotherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32902/2663-0338-2023-3-36-42\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infusion & Chemotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32902/2663-0338-2023-3-36-42","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景。依达拉奉是一种自由基清除剂,可抑制脂质过氧化,从而减少对脑细胞和其他器官的氧化损伤。依达拉奉主要被认为是治疗缺血性中风和肌萎缩侧索硬化症的有效药物。目标。探讨依达拉奉在临床应用时鲜为人知的可能性。
材料和方法。为了解决这个问题,在PubMed、Web of Science、Google Scholar和Scopus数据库中对全文文章进行了搜索和分析。搜索使用关键词“依达拉奉”进行,包括过去5年(2018年4月至2023年4月)的英语和乌克兰语出版物。结果。共鉴定和分析了518份出版物。依达拉奉已被发现可改善临床病程,并可用于治疗中枢神经系统疾病、抑郁症、创伤后应激障碍、认知功能障碍、肿瘤和传染病(特别是冠状病毒病)、许多中毒等。所有这些都表明需要进一步的临床研究来探索依达拉奉新的和意想不到的可能性。
New and little-known possibilities of edaravone in the treatment of cerebral stroke and extracranial pathology
BACKGROUND. Edaravone is a free radical scavenger and inhibits lipid peroxidation and thus reduces oxidative damage to brain cells and other organs. Edaravone is mainly known as an effective agent in the treatment of ischemic stroke and amyotrophic lateral sclerosis.
OBJECTIVE. To investigate the little-known possibilities of edaravone when it is used in clinical practice.
MATERIALS AND METHODS. To solve the task, a search and analysis of full-text articles was conducted in the PubMed, Web of Science, Google Scholar, and Scopus databases. The search was conducted using the key word “edaravone” and included English-language and Ukrainian-language publications over the past 5 years (from April 2018 to April 2023).
RESULTS. A total of 518 publications were identified and analyzed. Edaravone has been found to improve the clinical course and may be useful in the treatment of central nervous system diseases, depression, post-traumatic stress disorder, cognitive dysfunction, oncological and infectious diseases (in particular, coronavirus disease), many poisonings, etc. All this dictates the need for further clinical studies to explore new and unexpected possibilities of edaravone.