[不同品系及其杂交小鼠自发性和诱导性肝脏肿瘤发生的易感性不同]。

Eksperimental'naia onkologiia Pub Date : 1990-01-01
V I Kaledin, I A Serova, L A Semenova
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引用次数: 0

摘要

在小鼠中发现邻氨基偶氮甲苯诱导肝脏肿瘤的敏感性与这些肿瘤自发发展的易感性之间没有相关性。在杂交条件下,自发性肿瘤的易感性主要遗传,而对其诱导的敏感性则由中间型遗传。自发性肝癌在男性中更常见,而在相同基因型的女性中则更常见。
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[Different predisposition to the development of spontaneous and induced liver tumors in mice of different strains and their hybrids].

No correlation between the sensitivity to induction of liver tumours by ortho-aminoazotoluene and predisposition to spontaneous development of these tumours was found in mice. Under crossing the predisposition to spontaneous tumours was inherited dominantly, while sensitivity to their induction was inherited by the intermediate type. Spontaneous hepatomas were more frequent in males, whereas induced onesin females of the same genotype.

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