Moringa Oleifera Leaf Extract as an Antioxidant on Malondialdehyde (MDA) and Glutathione Peroxidase (GSH-Px) Levels in Rats with Hyperglycemia: A Systematic Literature Review

Hyperglycaemia is a clinical indicator of Diabetes Mellitus (DM), chronic hyperglycemia in diabetes is associated with damage to organ systems, such as kidney damage, eyes, nerves, and blood vessels, and even death through oxidative stress processes, resulting in an imbalance between antioxidants and free radicals. One of the plants that contain antioxidants is Moringa Oleifera (MO), MO has been utilized as a food source material. This plant has low toxicity, natural antioxidants, and important bioactive phytochemicals and is an excellent source of alternative natural therapies to synthetic drugs. Exogenous antioxidants in Moringa leaves may have potential as free radical scavengers. Studies published between 2017 and 2023 were systematically reviewed through identification in Research Gate, Science Direct, PubMed, and Google Scholar databases. Studies that met the inclusion criteria were included for review. The results of the literature review of the articles carried out can be concluded that the administration of moringa leaf extract is able to reduce blood sugar levels, reduce MDA levels and increase antioxidants in the body, such as Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px). Keywords: Hyperglycaemia, Diabetes, Leaf Extract Moringa Oleifera, Oxidative Stress, Antioxidant