与抗肿瘤检查点抑制剂治疗相关的关节病:目前对该问题的理解

A. D. Koltakova, A. M. Lila
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摘要

检查点抑制剂(CPI)是一种抗癌药物,可以激活针对癌细胞的免疫反应。这种类型的治疗非常有效,但也与许多免疫炎症并发症有关,包括肌肉骨骼。本文综述了目前对CPI患者免疫介导性关节病的临床表现、发病机制和治疗的认识。
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Arthropathy associated with antitumor checkpoint inhibitors therapy: current understanding of the problem
Checkpoint inhibitors (CPI) are anticancer drugs that activate the immune response against cancer cells. This type of treatment is highly effective, but also associates with many immunoinflammatory complications, including musculoskeletal. This review presents the current understanding of the clinical manifestations, pathogenesis and therapy of immune-mediated arthropathy in patients receiving CPI.
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