连续输注博来霉素对分级辐照下小鼠唇黏膜再生的影响。

NCI monographs : a publication of the National Cancer Institute Pub Date : 1988-01-01

L Vanuytsel, Y Feng, W Landuyt, E van der Schueren

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引用次数: 0

摘要

研究了博来霉素对分级辐照下小鼠唇粘膜细胞增殖的影响。以1天、7天或10天的间隔给药两个等大小的照射部分，同时和不同时给药40mg博来霉素/kg，连续sc输注，给药时间超过7天。在仅辐照的实验中，由于代偿性增殖，间隔时间从1天延长到7天导致等有效剂量的净增加。这种效果在10天的治疗间隔中更加明显。然而，博来霉素的加入几乎完全抑制了这种增殖活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of continuous infusion of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation.

The effect of the administration of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation was studied. Two equal-sized irradiation fractions were delivered with 1-, 7-, or 10-day intervals, with and without simultaneous administration of 40 mg bleomycin/kg in a continuous sc infusion, given over 7 days. In the experiments with irradiation only, the prolongation of the interval from 1 day to 7 days resulted in a net increase of the isoeffective dose due to compensatory proliferation. This effect was even more pronounced with the 10-day treatment interval. The addition of bleomycin, however, nearly completely suppressed this proliferative activity.

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NCI monographs : a publication of the National Cancer Institute

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