P物质和脑啡肽在大鼠导水管周围灰质中的分布。

Basic and applied histochemistry Pub Date : 1988-01-01
M Gioia, R Bianchi
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引用次数: 0

摘要

研究了与疼痛调节有关的两种神经肽P物质(SP)和Met-enk在导水管周围灰质(PAG)中的分布。本研究采用免疫细胞化学方法对“正常”和秋水仙碱处理的大鼠在不同的中脑水平上进行。SP免疫反应结构由均匀分布的纤维和神经元组成。后者在PAG腹侧特别多,其数量在尾颅方向增加。然而,在中脑轴上,没有观察到Met-enk元素的显著变化。在侧PAG中,Met-enk纤维最多,同时也有少量阳性细胞。本研究结果与文献报道的其他结果的比较表明,这两种神经肽的分布可能存在物种差异。结合PAG的生理和细胞结构特点,讨论了其免疫结构的分布。
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The distribution of substance P and met-enkephalin in the periaqueductal gray matter of the rat.

The distribution in the periaqueductal gray matter (PAG) of substance P (SP) and Met-enkephalin (Met-enk), two neuropeptides related to pain modulation, was investigated. The study was carried out at different mesencephalic levels, with immunocytochemical methods in both "normal" and colchicine treated rats. The SP immunoreactive structures are made up of uniformly distributed fibers and neurons. The latter are particularly numerous in the ventral PAG and their number increases in a caudo-cranial direction. Along the midbrain axis, however, no significant variation of the Met-enk elements was observed. The Met-enk fibers are most numerous in lateral PAG, together with the few positive cells, which are also present. The comparison between the present results and others reported in the literature suggests that there may be species differences in the distribution of the two neuropeptides. The distribution of immunostructures has been discussed in the light of the physiological and cytoarchitectural features of PAG.

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