1%特比萘芬乳膏与1%克霉唑乳膏治疗足癣的比较研究

Araz Hasan Mohammed, Gulikhan Ahmed Omer
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摘要

背景:足癣(运动足)是人体最常见的皮肤真菌感染。它可能持续短时间或长时间,并可能在治疗后复发。目的:评价和比较1%特比萘芬乳膏与1%克霉唑乳膏治疗足癣的有效性和安全性。患者与方法:在埃尔比勒市Rizgary教学医院皮肤科门诊进行随机对照试验。2019年3月至2020年1月。本研究纳入60例临床诊断为足癣的患者。30例患者局部应用1%特比萘芬乳膏,每日2次,持续1周;30例患者局部应用1%克曲霉唑乳膏,每日2次,持续4周。治疗前后进行真菌刮拭。以临床治愈率和真菌学治愈率评价疗效。临床和真菌学治愈率分别在第1、4和6周测量。结果:4周时,特比萘芬和克曲霉唑的真菌治愈率分别为86.7%和80%;6周时,特比萘芬和克曲霉唑的真菌治愈率分别为86.7%和90%。4周时,特比萘芬的临床治愈率为83.3%,克霉唑的临床治愈率为76.67%;6周时,特比萘芬的临床治愈率为83.3%,克霉唑的临床治愈率为83.3%。结论:1周特比萘芬1天2次与4周克曲霉唑1天2次在真菌学治疗和有效治疗方面效果相当。
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Comparative Study of Topical 1% Terbinafine Cream Versus 1% Clotrimazole Cream in The Treatment of Tineapedis
Background:Tinea pedis (athletic foot) is the most common dermatophytic fungal infection of the body. It may last for a short or long time and may recur after treatment. Objective: To assessed and compared the effectiveness and safety of 1% terbinafine cream and 1% clotrimazole cream for the treatment of tinea pedis. Patients and Methods: Randomized control trial was done in the outpatient clinic of dermatology department in Rizgary Teaching Hospital in Erbil. From March, 2019 to January, 2020. Sixty patients with tinea pedis diag-nosed clinically were included in this study. Thirty patients applied 1% terbinafine cream topically twice daily for one week and thirty patients applied 1% clotrimazole cream topically twice daily for four weeks. Scraping for fungi was performed before and after therapy. Efficacy was assessed by clini-cal cure and mycological cure. Clinical and mycological cure measured at weeks one, four and six. Results: Mycological cure rates were 86.7% for terbinafine and 80% for clotrimazole at 4 weeks, 86.7% for terbinafine and 90% for clotrimazole at 6 weeks. At 4 weeks, terbinafine had an 83.3 percent clinical treatment rate and clotrimazole had a 76.67 percent clinical treatment rate; at 6 weeks, terbinafine had an 83.3 percent clinical treatment rate and clotrimazole had an 83.3 percent clinical treatment rate. Conclusion: The study showed that one week terbinafine two times a day is as effective as four weeks clotrimazole two times a day as well as in terms of mycological treatments and efficient therapies.
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