白细胞介素-6和肿瘤坏死因子- α基因多态性与科威特阿拉伯患者银屑病关节炎遗传易感性的关系

Adel M. Al-Awadhi, Mohammad Z. Haider, Aminah M. Al-Awadi, Anita K. Kalarikkal, Jalaja Sukumaran, Eman AH Hasan, Youssef A. Bartella
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This study investigated the association of IL6 , IL13 and TNF - alpha gene polymorphisms with genetic susceptibility of PsA in Kuwaiti patients. Methods: The genotypes of IL6 gene (-174G/C; rs1800795), IL13 gene (R130Q; rs20541) and TNF-alpha gene (-308A/G’ rs1800629) polymorphisms were detected in 113 Kuwaiti PsA patients and were compared to that in 104 healthy controls. The PsA patients were diagnosed on the basis of the presence of inflammatory arthritis with psoriasis with no rheumatoid factor in the serum. The genotypes for IL6 , IL13 and TNF-alpha gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods and were confirmed by DNA sequencing. Results: The frequency of IL6 gene (-174G/C; rs1800795) and TNF-alpha gene (-308A/G’ rs1800629) polymorphisms manifested a statistically significant difference between Kuwaiti PsA patients and controls. 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引用次数: 0

摘要

背景:银屑病关节炎(Psoriatic arthritis, PsA)是一种伴有银屑病的关节炎症的炎性关节炎疾病。它是遗传、免疫和环境因素复杂相互作用的结果。在PsA中,T细胞的激活被认为是疾病过程中的关键步骤。t淋巴细胞影响表皮皮肤细胞的增殖并导致异常分化。细胞因子网络的改变已被证明在PsA的发病机制中起核心作用。银屑病以Th-1型细胞因子模式为特征,其中白细胞介素-6 (IL6)、白细胞介素-13 (IL13)和肿瘤坏死因子- α (tnf - α)的分泌有明显变化。本研究探讨了科威特患者中il - 6、il - 13和TNF - α基因多态性与PsA遗传易感性的关系。方法:il - 6基因分型(-174G/C;rs1800795), IL13基因(R130Q;在113名科威特PsA患者中检测到rs20541)和tnf - α基因(-308A/G ' rs1800629)多态性,并与104名健康对照进行比较。PsA患者在血清中无类风湿因子的基础上诊断为银屑病炎症性关节炎。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法确定IL6、IL13和tnf - α基因多态性的基因型,并进行DNA测序。结果:il - 6基因频率为-174G/C;rs1800795)和tnf - α基因(-308A/G ' rs1800629)多态性在科威特PsA患者与对照组之间存在统计学差异。然而,IL13基因(R130Q;rs20541)多态性在科威特PsA患者和对照组之间没有显着差异。结论:我们的数据显示两种细胞因子基因多态性在il - 6基因(-174G/C;rs1800795)和tnf - α基因(-308A/G ' rs1800629)在科威特患者中与PsA相关,突出了它们可能与其他因素一起对这种慢性疾病的遗传易感性有重要贡献。
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Association of Interleukin-6 and Tumor Necrosis Factor-alpha Gene Polymorphisms with Gnetic Susceptibility of Psoriatic Arthritis in Kuwaiti Arab Patients
Background: Psoriatic arthritis (PsA) is an inflammatory arthritic disease in which joint inflammation occurs with psoriasis. It results from a complex interplay between genetic, immunological and environmental factors. In PsA, the activation of T cells is considered as a crucial step in the disease process. The T-lymphocytes affect the proliferation of epidermal skin cells and result in abnormal differentiation. Altered cytokine networks have been shown to play a central role in the pathogenesis of PsA. Psoriasis is characterized by Th-1 type cytokine pattern in which there is a marked variation in the secretion of interleukin-6 (IL6), interleukin-13 (IL13) and Tumor necrosis factor-alpha (TNF-alpha). This study investigated the association of IL6 , IL13 and TNF - alpha gene polymorphisms with genetic susceptibility of PsA in Kuwaiti patients. Methods: The genotypes of IL6 gene (-174G/C; rs1800795), IL13 gene (R130Q; rs20541) and TNF-alpha gene (-308A/G’ rs1800629) polymorphisms were detected in 113 Kuwaiti PsA patients and were compared to that in 104 healthy controls. The PsA patients were diagnosed on the basis of the presence of inflammatory arthritis with psoriasis with no rheumatoid factor in the serum. The genotypes for IL6 , IL13 and TNF-alpha gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods and were confirmed by DNA sequencing. Results: The frequency of IL6 gene (-174G/C; rs1800795) and TNF-alpha gene (-308A/G’ rs1800629) polymorphisms manifested a statistically significant difference between Kuwaiti PsA patients and controls. However, the frequency of IL13 gene (R130Q; rs20541) polymorphism did not show a significant difference between Kuwaiti PsA patients and the controls. Conclusion: Our data show an association of two cytokine gene polymorphisms in IL6 gene (-174G/C; rs1800795) and TNF-alpha gene (-308A/G’ rs1800629) with PsA in Kuwaiti patients highlighting their significant contribution to genetic susceptibility of this chronic disease possibly along with other factors.
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来源期刊
Open Rheumatology Journal
Open Rheumatology Journal Medicine-Rheumatology
CiteScore
0.80
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0.00%
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2
期刊介绍: ENTHAM Open publishes a number of peer-reviewed, open access journals. These free-to-view online journals cover all major disciplines of science, medicine, technology and social sciences. BENTHAM Open provides researchers a platform to rapidly publish their research in a good-quality peer-reviewed journal. All peer-reviewed accepted submissions meeting high research and ethical standards are published with free access to all.
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